The "revolutionary" Boeing 787 Dreamliner planes will be flown out of Cardiff Airport for the first time.
Thomson Airways said it will be launching the flights next year.
They will be part of the Caribbean cruise and holiday programme for Thomson Cruises, Thomson Holidays, First Choice holidays and P&O Cruises.
Cardiff Airport said the 787 Dreamliners are Thomson's "newest, largest and most comfortable aircraft".
Karen Switzer, director of aviation planning for Thomson Airways said: "The Dreamliner has certainly lived up to its promise to revolutionise long haul travel.
"Feedback from both customer and crew has been extremely positive and we are delighted to be operating flights from Cardiff Airport where customers from Wales can now enjoy the Thomson 787 Dreamliner experience."
Boeing, which produces the planes made of carbon fibre and plastic, claims it is the world's most efficient aircraft.
Each aircraft can carry up to 291 passengers and fly as high as 38,000ft (11,500m).
Thomson had planned to use the 787s from May last year, but all 50 were grounded in January 2013 over faulty batteries.
(BBC News Wales)